Structure of PDB 7qei Chain A

Receptor sequence
>7qeiA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
MEAIIISGTEMAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTY
VRNKIRAASAVGICSELILKPKDVSQEELLDVTDQLNMDPRVSGILVQLP
LPDHVDERTICNGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEII
KRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRY
TPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVKLVGD
VDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKKIIY
3D structure
PDB7qei The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.15: methylenetetrahydrofolate dehydrogenase (NAD(+)).
1.5.1.5: methylenetetrahydrofolate dehydrogenase (NADP(+)).
3.5.4.9: methenyltetrahydrofolate cyclohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9L9 A Y98 K102 V145 Q146 L147 D169 Y292 L303 P323 G324 G327 P328 Y50 K54 V97 Q98 L99 D121 Y244 L247 P267 G268 G271 P272
BS02 ATR A G214 R215 S216 H246 R247 A267 A268 I270 G166 R167 S168 H198 R199 A219 A220 I222
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity

View graph for
Molecular Function
External links
PDB RCSB:7qei, PDBe:7qei, PDBj:7qei
PDBsum7qei
PubMed35712863
UniProtQ9H903|MTD2L_HUMAN Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (Gene Name=MTHFD2L)

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