Structure of PDB 7qdx Chain A

Receptor sequence
>7qdxA (length=402) Species: 83333,208964 [Search protein sequence]
IAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVT
EARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESAIVRDPVTVTPS
TKIIELLQMAREYGFSGFPVVEQGELVGIVTGRDLRVKPNGDTVAAIMTP
KDKLVTAREGTPLEEMKAKLYENRIEKMLVVDENFYLRGLVTFRDIEKAE
RKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSE
GVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGPICTT
RIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASA
VMVGSMLAGTEESPRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVR
IS
3D structure
PDB7qdx Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A V118 F138 E200 K201 L214 T216 R218 D219 V95 F115 E176 K177 L190 T192 R194 D195
BS02 ATP A I152 T154 R156 D157 T173 L178 V179 I199 E200 K201 I129 T131 R133 D134 T149 L154 V155 I175 E176 K177
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7qdx, PDBe:7qdx, PDBj:7qdx
PDBsum7qdx
PubMed37338125
UniProtP0ADG7;
Q9HXM5

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