Structure of PDB 7qc2 Chain A

Receptor sequence
>7qc2A (length=491) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
NILGITSKKIENFSDWYTQVIVKSELIEYYDISGCYILRPAAYYIWECVQ
AFFNKEIKKLNVENSYFPLFVTKNKLEKEKNHIEGFSPEVAWVTKYGDSN
LPEEIAIRPTSETIMYSVFPKWIRSYRDLPLKLNQWNTVVRWEFKQPTPF
IRTREFLWQEGHTAHKNEEEAVKLVFDILDLYRRWYEEYLAVPIIKGIKS
EGEKFGGANFTSTAEAFISENGRAIQAATSHYLGTNFAKMFKIEFEDENE
VKQYVHQTSWGCTTRSIGIMIMTHGDDKGLVLPPNVSKYKVVIVPIFTDE
NAIHSYCKDIEKILKNAQINCVYDDRASYSPGYKFNHWELRGIPIRIEVP
KDLQNNSCVIVRRDNNEKCNVKKESVLLETQQMLVDIHKNLFLKAKKKLD
DSIVQVTSFSEVMNALNKKKMVLAPWCEDIATEEEIKKETQRLSLNQSET
TLSGAMKPLCIPLDQPPMPPNMKCFWSGKPAKRWCLFGRSY
3D structure
PDB7qc2 Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline-tRNA ligase) from Plasmodium falciparum in complex with MAT334 and L-Proline
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRO A T359 E361 W407 E409 F454 H480 W509 G510 T110 E112 W158 E160 F205 H231 W260 G261
BS02 AJT A R390 E392 K394 F399 I400 R401 T402 F405 E452 Q475 T512 R514 R141 E143 K145 F150 I151 R152 T153 F156 E203 Q226 T263 R265
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qc2, PDBe:7qc2, PDBj:7qc2
PDBsum7qc2
PubMed
UniProtQ8I5R7|SYP_PLAF7 Proline--tRNA ligase (Gene Name=proRS)

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