Structure of PDB 7qbs Chain A

Receptor sequence

>7qbsA (length=411) Species: 2214 (Methanosarcina acetivorans) [Search protein sequence]

MEVVVDVGGNPGVDCKGFCKYCYFKKVKDIQPLGCKYCLPFKKGCDYCTR
SVKESYSGFKSLQMVLEETANKLYFTSGEVKKFTVSGGGDLSCYPELKSL
ITFLSQFNTPIHLGYTSGKGFSKPDDALFYIDNGVTEVSFTVFATDPALR
AEYMKDPEPEASIQVLRDFCTHCEVYGAIVLLPGINDGEVLEKTLCDLEN
MGAKGAILMRFANFQENGLILNNSPIIPGITPHTVSEFTEIVRSSAEKHP
SIRITGTPLEDPLIGSPFAIRNVPEALLKLPRVSKKATIITGQVAASRLT
EIFEALGGTVNVIPVKKDIGCLITIDDFKALDLSEVTETVFIPGRAFVHD
MEIKEALRRDGVDRIVRRGPERLSVDGEMSIGMTREEVLELEVENFTELI
GQINSLGLPLE

3D structure

PDB

7qbs Crystallographic snapshots of a B 12 -dependent radical SAM methyltransferase.

Chain

Resolution

2.327 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.379: [methyl coenzyme M reductase]-L-arginine C-5-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	D6 Y23 Y37 S51 E54 Y56 S86 G87 Y115 E137 S139 Y176 M209 E378	D6 Y23 Y37 S51 E54 Y56 S86 G87 Y115 E137 S139 Y176 M209 E378
BS02	SF4	A	C15 F18 C19 C22 S117 K119	C15 F18 C19 C22 S117 K119
BS03	FE	A	C35 C38 C45 C48	C35 C38 C45 C48
BS04	SAM	A	Y21 Y23 D90 Y115 T141 V180 F211 A212	Y21 Y23 D90 Y115 T141 V180 F211 A212
BS05	COB	A	Y23 F24 Y47 V52 R210 A212 N217 L219 I220 L221 N223 T257 P258 F268 T291 D318 I319 G320 C321 L322 F341 I342 P343 R345 F347 G369 P370 R372 L373 S374 D376 E378	Y23 F24 Y47 V52 R210 A212 N217 L219 I220 L221 N223 T257 P258 F268 T291 D318 I319 G320 C321 L322 F341 I342 P343 R345 F347 G369 P370 R372 L373 S374 D376 E378

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0008168	methyltransferase activity
GO:0035244	protein-arginine C-methyltransferase activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0032259	methylation
GO:0043687	post-translational protein modification

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7qbs, PDBe:7qbs, PDBj:7qbs
PDBsum	7qbs
PubMed	35110733
UniProt	Q8THG6\|MCRAM_METAC [Methyl coenzyme M reductase]-L-arginine C-5-methyltransferase (Gene Name=MA_4551)

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