Structure of PDB 7qbi Chain A

Receptor sequence
>7qbiA (length=298) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
APSLSNLFYDPTYNPGQSTINYTSIYGNGSTITFDELQGLVNSTVTQAIM
FGVRCGAAALTLIVMWMTSRSRKTPIFIINQVSLFLIILHSALYFKYLLS
NYSSVTYALTGFPQFISRGDVHVYGATNIIQVLLVASIETSLVFQIKVIF
TGDNFKRIGLMLTSISFTLGIATVTMYFVSAVKGMIVTYNDVSATQDKYF
NASTILLASSINFMSFVLVVKLILAIRSRRFLGLKQFDSFHILLIMSCQS
LLVPSIIFILAYSLKPNQGTDVLTTVATLLAVLSLPLSSMWATAANNA
3D structure
PDB7qbi Activation mechanism of the class D fungal GPCR dimer Ste2.
ChainA
Resolution3.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q51 H94 Y101 Y128 T131 N132 Q135 Y181 A198 D201 F204 N205 Y266 L268 D275 V276 T279 Q47 H90 Y97 Y124 T127 N128 Q131 Y177 A194 D197 F200 N201 Y262 L264 D271 V272 T275
BS02 Y01 A F99 K100 L103 F95 K96 L99
BS03 Y01 A T50 I53 M54 Q272 T46 I49 M50 Q268
BS04 Y01 A A206 I209 A202 I205
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004932 mating-type factor pheromone receptor activity
GO:0004934 mating-type alpha-factor pheromone receptor activity
GO:0005515 protein binding
Biological Process
GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0000755 cytogamy
GO:0007186 G protein-coupled receptor signaling pathway
GO:0019236 response to pheromone
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0038038 G protein-coupled receptor homodimeric complex

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Cellular Component
External links
PDB RCSB:7qbi, PDBe:7qbi, PDBj:7qbi
PDBsum7qbi
PubMed35296853
UniProtD6VTK4|STE2_YEAST Pheromone alpha factor receptor (Gene Name=STE2)

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