Structure of PDB 7qbe Chain A

Receptor sequence
>7qbeA (length=394) Species: 9606 (Homo sapiens) [Search protein sequence]
EMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTK
EDLYLHSLKLGYQQCLLGCQGKPSMGQLALYLLALRANCEFVRGHKGDRL
VSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVD
KLLYAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVQ
EEILKAQTPEGHFGNVYSTPLALQFLMTSPMRGAELGTACLKARVALLAS
LQDGAFQNALMISQLLPVLNHKTYIDLIFPDCLAPRVMLEPAAQEIISVT
LQVLSLLPPYRQSISVLAGSTVEDVLKKAHELGGFTYETQASLSGPYLTS
VMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETIELRLVSW
3D structure
PDB7qbe Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CNC A Q86 Y137 Q138 D176 N224 Y226 M270 S357 L358 S359 G360 P361 Y362 L363 F376 W377 Q378 L379 L387 L388 G390 W409 Q77 Y128 Q129 D167 N215 Y217 M261 S342 L343 S344 G345 P346 Y347 L348 F361 W362 Q363 L364 L372 L373 G375 W394
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
GO:0140355 cargo receptor ligand activity
Biological Process
GO:0006824 cobalt ion transport
GO:0015889 cobalamin transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0043202 lysosomal lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qbe, PDBe:7qbe, PDBj:7qbe
PDBsum7qbe
PubMed35218573
UniProtP20062|TCO2_HUMAN Transcobalamin-2 (Gene Name=TCN2)

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