Structure of PDB 7qb7 Chain A

Receptor sequence
>7qb7A (length=486) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
NILGITSKKIENFSDWYTQVIVKSELIEYYDISGCYILRPAAYYIWECVQ
AFFNKEIKKLNVENSYFPLFVTKNKLEKEFSPEVAWVTKYGDSNLPEEIA
IRPTSETIMYSVFPKWIRSYRDLPLKLNQWNTVVRWEFKQPTPFIRTREF
LWQEGHTAHKNEEEAVKLVFDILDLYRRWYEEYLAVPIIKGIKSEGEKFG
GANFTSTAEAFISENGRAIQAATSHYLGTNFAKMFKIEFEDENEVKQYVH
QTSWGCTTRSIGIMIMTHGDDKGLVLPPNVSKYKVVIVPIFYKTTDENAI
HSYCKDIEKILKNAQINCVYDDRASYSPGYKFNHWELRGIPIRIEVGPKD
LQNNSCVIVRRDNNEKCNVKKESVLLETQQMLVDIHKNLFLKAKKKLDDS
IVQVTSFSEVMNALNKKKMVLAPWCEDIATEEEIKKETQRLSLNTTLSGA
MKPLCIPLDQPPMPPNMKCFWSGKPAKRWCLFGRSY
3D structure
PDB7qb7 Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline-tRNA ligase) from Plasmodium falciparum in complex with MAT345
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRO A T359 E361 W407 E409 F454 H480 S508 W509 G510 T104 E106 W152 E154 F199 H225 S253 W254 G255
BS02 9X2 A R390 E392 K394 F399 I400 R401 T402 F405 E452 Q475 T478 T512 R514 R135 E137 K139 F144 I145 R146 T147 F150 E197 Q220 T223 T257 R259
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qb7, PDBe:7qb7, PDBj:7qb7
PDBsum7qb7
PubMed
UniProtQ8I5R7|SYP_PLAF7 Proline--tRNA ligase (Gene Name=proRS)

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