Structure of PDB 7q8y Chain A

Receptor sequence
>7q8yA (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
EQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQ
QPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLR
RSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPST
CRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGR
HDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEF
SIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEK
3D structure
PDB7q8y TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9IV A I35 C78 M94 Q97 N100 D103 S145 L162 I30 C73 M89 Q92 N95 D98 S140 L157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7q8y, PDBe:7q8y, PDBj:7q8y
PDBsum7q8y
PubMed34978799
UniProtQ6IQ55|TTBK2_HUMAN Tau-tubulin kinase 2 (Gene Name=TTBK2)

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