Structure of PDB 7q8t Chain A

Receptor sequence
>7q8tA (length=465) Species: 10090 (Mus musculus) [Search protein sequence]
EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKYEETVFYGLQYILNK
YLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKA
VPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQ
KKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGT
DTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQ
FSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPL
DTVLKVLDILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGM
KQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPV
ADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGHDLLHTVFKNGKVT
KSYSFDEVRKNAQLN
3D structure
PDB7q8t Crystal structure of NAMPT bound to ligand TSY535(compound 9a)
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.12: nicotinamide phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9IY A H191 F193 R196 Y240 V242 A244 S275 I309 R311 I351 G353 S379 H173 F175 R178 Y222 V224 A226 S257 I291 R293 I333 G335 S361
BS02 9IY A Y18 R392 K400 Y11 R374 K382
Gene Ontology
Molecular Function
GO:0005125 cytokine activity
GO:0016757 glycosyltransferase activity
GO:0042802 identical protein binding
GO:0047280 nicotinamide phosphoribosyltransferase activity
Biological Process
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0032922 circadian regulation of gene expression
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0030054 cell junction

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7q8t, PDBe:7q8t, PDBj:7q8t
PDBsum7q8t
PubMed36873168
UniProtQ99KQ4|NAMPT_MOUSE Nicotinamide phosphoribosyltransferase (Gene Name=Nampt)

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