Structure of PDB 7q87 Chain A

Receptor sequence

>7q87A (length=323) Species: 2026 (Thermoactinomyces vulgaris)

DFPSYDSGYHNYNEMVNKINTVASNYPNIVKKFSIGKSYEGRELWAVKIS
DNVGTDENEPEVLYTALHHAREHLTVEMALYTLDLFTQNYNLDSRITNLV
NNREIYIVFNINPDGGEYDISSGSYKSWRKNRQPNSGSSYVGTDLNRNYG
YKWGCCGGSSGSPSSETYRGRSAFSAPETAAMRDFINSRVVGGKQQIKTL
ITFHTYSELILYPYGYTYTDVPSDMTQDDFNVFKTMANTMAQTNGYTPQQ
ASDLYITDGDMTDWAYGQHKIFAFTFEMYPTSYNPGFYPPDEVIGRETSR
NKEAVLYVAEKADCPYSVIGKSC

3D structure

• PDB: 7q87 Carboxypeptidase T with (S)-3-phenyllactic acid
• Chain: A
• Resolution: 1.73 Å

Enzymatic activity

• Enzyme Commision number: 3.4.17.18: carboxypeptidase T.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H69 E72 H204	H69 E72 H204
BS02	HFA	A	H69 R129 L211 A251 L254 Y255 E277	H69 R129 L211 A251 L254 Y255 E277
BS03	HFA	A	H69 E72 R129 H204 T205 Y206 Y255 E277	H69 E72 R129 H204 T205 Y206 Y255 E277
BS04	CA	A	S50 D51 E57 E59	S50 D51 E57 E59
BS05	CA	A	D56 E57 E61 E104	D56 E57 E61 E104
BS06	CA	A	S7 Y9 E14	S7 Y9 E14
BS07	CA	A	Y5 D291 E292	Y5 D291 E292
BS08	CA	A	D51 E59 N101	D51 E59 N101
BS09	CA	A	Y218 D220 Q250	Y218 D220 Q250

Gene Ontology

Molecular Function

• GO:0004181 metallocarboxypeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:7q87, PDBe:7q87, PDBj:7q87
• PDBsum: 7q87
• UniProt: P29068|CBPT_THEVU Carboxypeptidase T (Gene Name=cpt)