Structure of PDB 7q6z Chain A

Receptor sequence
>7q6zA (length=485) Species: 9606 (Homo sapiens) [Search protein sequence]
MLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGG
LKKDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLY
GMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQ
GVEEVKRRWYKTENEYYLLQFTLTVRCLYYTNFSLELCTSYSFPWMLAYV
FYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGRLLCWWWLA
ELMAHLMYMHAIYSSIPLLETVSCWTLGGLALAQVLFFYVKYLVLFGVPA
LLMRLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPVGGSQ
HGLLGTLFSTAMTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVET
PCIQDSLARYFSPQARRRFHAALASCSTSMLILSNLVFLGGNEVGKTYWN
RIFIQGWPWVTLSVLGFLYCYSHVGIAWAQTYATD
3D structure
PDB7q6z Structure, mechanism, and inhibition of Hedgehog acyltransferase.
ChainA
Resolution3.59 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A M64 K68 L71 M64 K68 L71
BS02 HEM A H18 R250 W254 L257 L294 Y297 R323 C324 S326 T327 W486 H18 R242 W246 L249 L286 Y289 R315 C316 S318 T319 W478
BS03 9V3 A V293 Y300 M334 W335 F338 N392 N443 F446 V285 Y292 M326 W327 F330 N384 N435 F438
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008374 O-acyltransferase activity
GO:0016409 palmitoyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0007224 smoothened signaling pathway
GO:0018009 N-terminal peptidyl-L-cysteine N-palmitoylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7q6z, PDBe:7q6z, PDBj:7q6z
PDBsum7q6z
PubMed34890564
UniProtQ5VTY9|HHAT_HUMAN Protein-cysteine N-palmitoyltransferase HHAT (Gene Name=HHAT)

[Back to BioLiP]