Structure of PDB 7q4l Chain A

Receptor sequence
>7q4lA (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
GAMERVNPENKAALEAWVRETGIRLVQVNGQRKYGGPPPGWVGSPPPAGS
EVFIGRLPQDVYEHQLIPLFQRVGRLYEFRLMMTFSGLNRGFAYARYSSR
RGAQAAIATLHNHPLRPSCPLLVCRSTEKCELSVDGLPPNLTRSALLLAL
QPLGPGLQEARLLPSPGPAPGQIALLKFSSHRAAAMAKKALVEGQSHLCG
EQVAVEWLKPDLKQRLRQQLVGPFLRS
3D structure
PDB7q4l The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A N37 Q39 F61 R64 R88 M90 M91 T92 F93 S94 F100 Y102 H119 L130 C132 T135 K137 H189 K196 K197 W215 N29 Q31 F53 R56 R80 M82 M83 T84 F85 S86 F92 Y94 H111 L122 C124 T127 K129 H181 K188 K189 W207
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:7q4l, PDBe:7q4l, PDBj:7q4l
PDBsum7q4l
PubMed36202814
UniProtQ8IYX4|DND1_HUMAN Dead end protein homolog 1 (Gene Name=DND1)

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