Structure of PDB 7q1x Chain A

Receptor sequence
>7q1xA (length=266) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
MTDLNIPHTHAHLVDAFQALGIRAGQALMLHASVKAVGAVMGGPNVILQA
LMDALTPDGTLMMYAGWQDIPDFIDSLPDALKAVYLEQHPPFDPATARAV
RENSVLAEFLRTWPCVHRSANPEASMVAVGRQAALLTANHALDYGYGVES
PLAKLVAIEGYVLMLGAPLDTITLLHHAEYLAKMRHKNVVRYPCPILRDG
RKVWVTVEDYDTGDPHDDYSFEQIARDYVAQGGGTRGKVGDADAYLFAAQ
DLTRFAVQWLESRFGD
3D structure
PDB7q1x The 3-N-alkylation of the neomycin B outmaneuvers the aminoglycoside resistant enzyme acetyltransferase(3)IIIa via an unexpected mechanism
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.81: aminoglycoside N(3)-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NMY A E143 Y166 D190 H196 T232 D234 E123 Y146 D170 H176 T212 D214
Gene Ontology
Molecular Function
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046353 aminoglycoside 3-N-acetyltransferase activity
GO:0120225 coenzyme A binding
Biological Process
GO:0016999 antibiotic metabolic process
GO:0046356 acetyl-CoA catabolic process
GO:0046677 response to antibiotic
GO:0071236 cellular response to antibiotic
GO:1901742 2-deoxystreptamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7q1x, PDBe:7q1x, PDBj:7q1x
PDBsum7q1x
PubMed
UniProtP29808|AACC3_PSEAI Aminoglycoside N(3)-acetyltransferase III (Gene Name=aacC3)

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