Structure of PDB 7pxg Chain A

Receptor sequence
>7pxgA (length=885) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
LKVRKYWCFLLSSIFTFLAGLLVVLLWRAFAFVCTFMTEAKDWAGELISG
QTTTGRILVVLVFILSIASLIIYFVDASSEEVERCQKWSNNITQQIDLAF
NIFFMVYFFIRFIAASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGL
RFLRALRLMTVPDILQYLNVLKTSSSIRLAQLVSIFISVWLTAAGIIHLL
ENSGDPLDFDNAHRLSYWTCVYFLIVTMSTVGYGDVYCETVLGRTFLVFF
LLVGLAIFASCIPEIIDLIGTRAKYGGTLKNEKGRRHIVVCGHITYESVS
HFLKDFLHEDREDVDVEVVFLHRKPPDLELEGLFKRHFTTVEFFQGTIMN
PIDLQRVKVHEADACLVLANKYCQDPDAEDAANIMRVISIKNYSDDIRVI
IQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFIAQSCLAPGFSTMM
ANLFAMRSFKTSPDMQSWTNDYLRGTGMEMYTETLSPTFIGIPFAQATEL
CFSKLKLLLLAIEIKSKISINPRGAKIQANTQGFFIAQSADEVKRAWFYC
KAMKYDSTGMFHWSPAKSLEDCILDRNQAAMTVLNGHVVVCLFADPDSPL
IGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNG
SPLSRADLRAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASLNIKAMT
FDVYGANVPMITELVNDGNVQFLDQDDDDDPDTELYLTQPFACGTAFAVS
VLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTVES
LSNRDRCRVGQISLYDGPLAQFGECGKYGDLFVAALKSYGMLCIGLYRFR
DTSASSKRYVITNPPDDFSLLPTDQVFVLMQFDPG
3D structure
PDB7pxg Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM.
ChainA
Resolution2.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8H5 A F257 M299 T301 F321 L322 G325 L326 I328 F329 F186 M228 T230 F250 L251 G254 L255 I257 F258
BS02 CA A Q977 D980 D983 D985 Q721 D724 D727 D729
BS03 CA A D381 R528 G548 E550 Q616 D310 R457 G477 E479 Q538
BS04 MG A N523 A526 T547 M549 E550 N452 A455 T476 M478 E479
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0015269 calcium-activated potassium channel activity
GO:0060072 large conductance calcium-activated potassium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0007623 circadian rhythm
GO:0008582 regulation of synaptic assembly at neuromuscular junction
GO:0009410 response to xenobiotic stimulus
GO:0045433 male courtship behavior, veined wing generated song production
GO:0048512 circadian behavior
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:1900074 negative regulation of neuromuscular synaptic transmission
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045211 postsynaptic membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pxg, PDBe:7pxg, PDBj:7pxg
PDBsum7pxg
PubMed34887422
UniProtQ03720|SLO_DROME Calcium-activated potassium channel slowpoke (Gene Name=slo)

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