Structure of PDB 7pup Chain A

Receptor sequence
>7pupA (length=479) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
GPMKGVLLDESVLFSPESEDPSLRESVPSLLRLLRYSMIRTGISYGLDLP
ENKVDLLRKTAAEYSINCLPLETSLTSVTFGDTLKAWYSDGSILYVASSR
KEEILRELSPSQLVVLLEGDSLEDPNIIHIHSLEELPMTICCINKKAMGD
GAAIVAYIMKPSRVEDFAKRGALPMYPTSCGLIFLPLMFEFPLASQLKHA
DIIFHKATDEILSIELNCSDSKSSVAVTFSTGMEKLKKYMEDQNACAIVD
PIRNIYPVVDRLKMQHILLGLEGLGAAGRKIRGACFLKIDSYDEPDLAQN
LSRAGLSLPCIVKPQVACGVADAHSMAIVFRVEDFKNLNTPVPAIIQEYV
DHSSRIFKFYVLGETIFHAVKKSIPSSSSLRKSAEENGLKPILFDSLKSL
PVDSANVSEIDLELVTEAATWLRKKLDLTIFGFDVVIQEGTGDHVIVDLN
YLPSFKEVPDNIAVPAFWEAIRNRFDQHV
3D structure
PDB7pup A haloalkanoic acid halogenase fold in a diversified inositol tris/tetrakisphosphate kinase family reveals the prokaryotic origins of InsP6 synthesis
ChainA
Resolution1.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.159: inositol-1,3,4-trisphosphate 5/6-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A R263 K315 H326 M328 Q349 Y351 V352 H354 I358 S375 I376 S398 V452 D453 R261 K313 H324 M326 Q347 Y349 V350 H352 I356 S373 I374 S396 V447 D448
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
GO:0047325 inositol-3,4,5,6-tetrakisphosphate 1-kinase activity
GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity
GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity
Biological Process
GO:0010264 myo-inositol hexakisphosphate biosynthetic process
GO:0016310 phosphorylation
GO:0032957 inositol trisphosphate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7pup, PDBe:7pup, PDBj:7pup
PDBsum7pup
PubMed36896917
UniProtO80568|ITPK4_ARATH Inositol 1,3,4-trisphosphate 5/6-kinase 4 (Gene Name=ITPK4)

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