Structure of PDB 7prx Chain A

Receptor sequence
>7prxA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
TPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWA
KAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLI
INEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKD
GLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEV
VENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB7prx Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I572 V575 K579 R585 L589 M593 E751 M752 E755 I44 V47 K51 R57 L61 M65 E223 M224 E227
BS02 82H A P541 L563 N564 L566 G567 Q570 A574 M604 A607 L608 F623 M639 Q642 C643 C736 T739 F749 P13 L35 N36 L38 G39 Q42 A46 M76 A79 L80 F95 M111 Q114 C115 C208 T211 F221
External links
PDB RCSB:7prx, PDBe:7prx, PDBj:7prx
PDBsum7prx
PubMed36747092
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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