Structure of PDB 7prw Chain A

Receptor sequence

>7prwA (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]

GPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCI
IDKIRRKNCPACRYRKCLQAGMNLPQLTPTLVSLLEVIEPEVLYAGYDSS
VPDSTWRIMTTLNMLGGRQMIAAVKWAKAIPGFRNLHLDDQMTLLQYSWM
SLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPDMYDQCKHMLYVSS
ELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAI
VKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPE
MLAEIITNQIPKYSNGNIKKLLFHQK

3D structure

PDB

7prw Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.

Chain

Resolution

2.502 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	G439 S440 R447 R470 R477	G25 S26 R33 R56 R63
BS02	dna	A	C431 H432 Y433 K442 K471	C17 H18 Y19 K28 K57
BS03	peptide	A	K579 R585 M593 E751 M752 E755	K128 R134 M142 E300 M301 E304
BS04	ZN	A	C421 C424 C438 C441	C7 C10 C24 C27
BS05	ZN	A	C463 C473 C476	C49 C59 C62
BS06	82H	A	P541 M560 L563 N564 L566 G567 Q570 A574 M604 A607 L608 R611 F623 Q642 C643 K667 C736 T739	P90 M109 L112 N113 L115 G116 Q119 A123 M153 A156 L157 R160 F172 Q191 C192 K216 C285 T288

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:7prw, PDBe:7prw, PDBj:7prw
PDBsum	7prw
PubMed	36747092
UniProt	P04150\|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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