Structure of PDB 7ppn Chain A

Receptor sequence
>7ppnA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
SGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHD
GDPNEPVSDYINANIIMPEFGSSGKKSYIATQGCLQNTVNDFWRMVFQEN
SRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLR
ELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESI
MDAGPVVVHSSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRS
QRSGMVQTEAQYRFIYMAVQHYIETLQRR
3D structure
PDB7ppn Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y38 K39 N40 S213 S214 A215 I217 G218 R219 Q260 Y35 K36 N37 S210 S211 A212 I214 G215 R216 Q257
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ppn, PDBe:7ppn, PDBj:7ppn
PDBsum7ppn
PubMed36114179
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

[Back to BioLiP]