Structure of PDB 7poz Chain A

Receptor sequence
>7pozA (length=405) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
MSVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWD
SPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYD
CPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASG
FCYLNDIVLAIHRLVSSQTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVH
HASPGFFPGTGTWNMVLPIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIG
PILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPLSGYLYAIKKI
LSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHS
YFSRYGPDFELDIDYFPHKSLDSIQKHHRRILEQLRNYADLNKLIYDYDQ
VYQLY
3D structure
PDB7poz Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D186 H188 D285 D177 H179 D272
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006338 chromatin remodeling
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7poz, PDBe:7poz, PDBj:7poz
PDBsum7poz
PubMed35970392
UniProtA5H660

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