Structure of PDB 7poy Chain A

Receptor sequence
>7poyA (length=328) Species: 227321 (Aspergillus nidulans FGSC A4) [Search protein sequence]
VSKANVPKIDVSPLFGDDQAAKMRVAQQIDAASRDTGFFYAVNHGINVQR
LCQKTKEFHMSITPEEKWDLAIRAYNKEHQDQVRAGYYLSIPGKKAVESF
CYLNPNFTPDHPRIQAKTPTHEVNVWPDETKHPGFQDFAEQYYWDVFGLS
SALLKGYALALGKEENFFARHFKPDDTLASVVLIRYPYLDPYPEAAIKTA
ADGTKLSFEWHEDVSLITVLYQSNVQNLQVETAAGYQDIEADDTGYLINC
GSYMAHLTNNYYKAPIHRVKWVNAERQSLPFFVNLGYDSVIDPFDPREPN
GKSDREPLSYGDYLQNGLVSLINKNGQT
3D structure
PDB7poy Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.21.3.1: isopenicillin-N synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H214 D216 H270 H211 D213 H267
BS02 ACV A R87 S183 Y189 H214 D216 F285 R84 S180 Y186 H211 D213 F282
BS03 NO A H214 H270 H211 H267
BS04 81T A V51 C55 Y224 D246 V48 C52 Y221 D243
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016216 isopenicillin-N synthase activity
GO:0016491 oxidoreductase activity
GO:0031418 L-ascorbic acid binding
GO:0046872 metal ion binding
Biological Process
GO:0009058 biosynthetic process
GO:0017000 antibiotic biosynthetic process
GO:0042318 penicillin biosynthetic process
GO:0044283 small molecule biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7poy, PDBe:7poy, PDBj:7poy
PDBsum7poy
PubMed35835215
UniProtP05326|IPNA_EMENI Isopenicillin N synthase (Gene Name=ipnA)

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