Structure of PDB 7pmx Chain A

Receptor sequence
>7pmxA (length=657) Species: 9606 (Homo sapiens) [Search protein sequence]
YPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDNLSTAIYHTFVAL
CYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDSLPV
HVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAI
NAGSLLSTIITPMLRVQQQACYPLAFGVPAALMAVALIVFVLGSGMYKKF
KPQGNIMGKVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQ
IKMVTRVMFLYIPLPMFWALFDQQGSRWTLQATTMSGKIGALEIQPDQMQ
TVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKKMAVGMVLASMAFVVAA
IVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGPMSQTNA
FMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDG
LNQKPEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIK
GFTISSTEIPPQCQPNFNTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISA
NTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTV
AVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVCVIFAIMARFYTYINPA
EIEAQFD
3D structure
PDB7pmx Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
ChainA
Resolution3.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R27 Y31 Y167 N171 E595 R16 Y20 Y147 N151 E569
Gene Ontology
Molecular Function
GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0015333 peptide:proton symporter activity
GO:0022857 transmembrane transporter activity
GO:0035673 oligopeptide transmembrane transporter activity
GO:0042937 tripeptide transmembrane transporter activity
GO:0071916 dipeptide transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006857 oligopeptide transport
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0055085 transmembrane transport
GO:0140206 dipeptide import across plasma membrane
GO:0140207 tripeptide import across plasma membrane
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016324 apical plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pmx, PDBe:7pmx, PDBj:7pmx
PDBsum7pmx
PubMed34730990
UniProtP46059|S15A1_HUMAN Solute carrier family 15 member 1 (Gene Name=SLC15A1)

[Back to BioLiP]