Structure of PDB 7phd Chain A

Receptor sequence
>7phdA (length=313) Species: 1950,1114943 [Search protein sequence]
LRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPEALL
RLIRHLVAIGLLEEFVPTEVGELLADDHPAAQRAWHDLTQAVARADISFT
RLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLLACDQDVAFDAP
AAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMAGTVDTARSY
LKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHDAVRILTRCA
EALEPGGRILIHESDFSVLDLRMLVFLGGALRTREKWDGLAASAGLVVEE
VRQLLSLLVLAPA
3D structure
PDB7phd Evolution-inspired engineering of anthracycline methyltransferases.
ChainA
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.292: carminomycin 4-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A Y143 R153 F156 L160 F168 G187 E210 M211 G236 D237 F238 S252 F253 Y122 R132 F135 L139 F147 G166 E189 M190 G215 D216 F217 S231 F232
BS02 3VL A W106 F156 L160 D163 F253 V302 L303 R306 M307 F310 W85 F135 L139 D142 F232 V268 L269 R272 M273 F276
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7phd, PDBe:7phd, PDBj:7phd
PDBsum7phd
PubMed36874276
UniProtI2N5E8;
Q06528|DNRK_STRPE Carminomycin 4-O-methyltransferase DnrK (Gene Name=dnrK)

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