Structure of PDB 7ph4 Chain A

Receptor sequence
>7ph4A (length=576) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
DKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLD
DGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRR
LFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASI
IGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQV
TTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDP
IIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTN
VNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPG
RDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMD
GHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEA
ARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILI
LDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVED
GVIVERGTHNDLLEHRGVYAQLHKMQ
3D structure
PDB7ph4 The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.5.2.6: ABC-type lipid A-core oligosaccharide transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A Y351 S378 G379 S380 G381 K382 S383 T384 Q424 H537 Y348 S375 G376 S377 G378 K379 S380 T381 Q421 H534
BS02 MG A S383 Q424 S380 Q421
BS03 ANP A L480 S482 G484 Q485 L477 S479 G481 Q482
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0008559 ABC-type xenobiotic transporter activity
GO:0015437 lipopolysaccharide floppase activity
GO:0016887 ATP hydrolysis activity
GO:0034040 ATPase-coupled lipid transmembrane transporter activity
GO:0042802 identical protein binding
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006869 lipid transport
GO:0015920 lipopolysaccharide transport
GO:0034204 lipid translocation
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:1990199 MsbA transporter complex

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Cellular Component
External links
PDB RCSB:7ph4, PDBe:7ph4, PDBj:7ph4
PDBsum7ph4
PubMed36223470
UniProtP60752|MSBA_ECOLI ATP-dependent lipid A-core flippase (Gene Name=msbA)

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