Structure of PDB 7ph3 Chain A

Receptor sequence
>7ph3A (length=577) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
NDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLL
DDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRR
RLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGAS
IIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQ
VTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISD
PIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLT
NVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYP
GRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILM
DGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEE
AARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPIL
ILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVE
DGVIVERGTHNDLLEHRGVYAQLHKMQ
3D structure
PDB7ph3 The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.5.2.6: ABC-type lipid A-core oligosaccharide transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A Y351 S378 G379 G381 K382 S383 T384 Q424 H537 Y349 S376 G377 G379 K380 S381 T382 Q422 H535
BS02 MG A S383 Q424 S381 Q422
BS03 ANP A L480 S482 G484 Q485 L478 S480 G482 Q483
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0008559 ABC-type xenobiotic transporter activity
GO:0015437 lipopolysaccharide floppase activity
GO:0016887 ATP hydrolysis activity
GO:0034040 ATPase-coupled lipid transmembrane transporter activity
GO:0042802 identical protein binding
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006869 lipid transport
GO:0015920 lipopolysaccharide transport
GO:0034204 lipid translocation
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:1990199 MsbA transporter complex

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Cellular Component
External links
PDB RCSB:7ph3, PDBe:7ph3, PDBj:7ph3
PDBsum7ph3
PubMed36223470
UniProtP60752|MSBA_ECOLI ATP-dependent lipid A-core flippase (Gene Name=msbA)

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