Structure of PDB 7pgn Chain A

Receptor sequence
>7pgnA (length=437) Species: 9606 (Homo sapiens) [Search protein sequence]
KHNCFCIQEVVSGLRQPVGALHSGDGSQRLFILEKEGYVKILTPEGEIFK
EPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQHDHIL
RVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFGPDGFLYIIL
GDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTN
QPPEVFAHGLHDPGRCAVDRHNINLTILCSDSNGSSARILQIIKGKDYES
EPSLLEFKPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQ
EKPLCLGTSGSCRGYFSGHILGFGEDELGEVYILSSSKSQTHNGKLYKIV
DPKRPLMPEECRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDF
CRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVD
3D structure
PDB7pgn Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GU4 A R514 K569 R283 K338
BS02 YYJ A K277 G278 G279 K351 K65 G66 G67 K132
External links
PDB RCSB:7pgn, PDBe:7pgn, PDBj:7pgn
PDBsum7pgn
PubMed34887403
UniProtQ96QV1|HHIP_HUMAN Hedgehog-interacting protein (Gene Name=HHIP)

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