Structure of PDB 7pg0 Chain A

Receptor sequence
>7pg0A (length=786) Species: 9606 (Homo sapiens) [Search protein sequence]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCC
HSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSF
CQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTRQERNDIALK
TNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEA
PYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQ
IILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCHRPFEKVVNKESL
VISGLRHFTGYRIELQACNQDERCSVAAYVSARTMPEAKADDIVGPVTHE
IFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERG
CRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTD
3D structure
PDB7pg0 Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
ChainA
Resolution7.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D12 R14 N15 L37 F39 D12 R14 N15 L37 F39
BS02 peptide A R488 P537 K544 S545 Q546 N547 R478 P527 K534 S535 Q536 N537
BS03 peptide A Y477 L486 R488 N547 H548 Y467 L476 R478 N537 H538
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pg0, PDBe:7pg0, PDBj:7pg0
PDBsum7pg0
PubMed35074483
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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