Structure of PDB 7pci Chain A

Receptor sequence
>7pciA (length=345) Species: 271848 (Burkholderia thailandensis E264) [Search protein sequence]
DLIYQDEHASLQPLEGRTVAVIGYGIQGRAFAANLRDSGVAVRVGNIDDR
YFELARAEGHRVTNIAEAVAHADIVLLLIPDEAHGAVFDVDIAPNLRDGA
LLCVAHGHSLVQGDVRPLPGRDLAMLAPRMYGDPIRRYYLAGQGAPAYFD
IVADHTGRARDRVLAIARAVGFTRAGVMALGYRQETFLDLFQEQFLAPAL
VDLVETGFQVLVERGFNPKAALLEVYGSGEMGKMMLDGADIGLDEVVALQ
GSPTCQVGYHRWRGRTLPTAVRELAARVLDQIEGGDFSAYLKEQASNDYA
SLDDARRAALKRPLNVAHAQVRAAFRFPTEAAGGLYQAAQAPADV
3D structure
PDB7pci Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.86: ketol-acid reductoisomerase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G25 G27 I28 Q29 N48 I49 D51 Y53 I81 P82 D83 A85 H86 V89 A107 H108 Y133 G23 G25 I26 Q27 N46 I47 D49 Y51 I79 P80 D81 A83 H84 V87 A105 H106 Y131
BS02 MG A D191 E195 D189 E193
BS03 74I A D191 E195 D189 E193
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004455 ketol-acid reductoisomerase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009099 L-valine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7pci, PDBe:7pci, PDBj:7pci
PDBsum7pci
PubMed35906404
UniProtQ2T3G7

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