Structure of PDB 7pag Chain A

Receptor sequence
>7pagA (length=509) Species: 10090 (Mus musculus) [Search protein sequence]
PCYTATRSECKQKHKFVPGVWMAGEGMDVTTLRRSGSFPVNTQRFLRPDR
TCTLCKNSLMRDATQRLPVAITHWRPHSSHCQRNVAAAKVHSTEGVAREA
AANINNDWRVGLDVNPRPEANMRASVAGSHSKVANFAAEKTYQDQYNFNS
DTVECRMYSFRLVQKPPLHLDFKKALRALPRNFNSSTEHAYHRLISSYGT
HFITAVDLGGRISVLTALRTCQLTLNGLTADEVGDCLNVEAQVSIGAQAS
VSSEYKACEEKKKQHKMATSFHQTYRERHVEVLGGPLDSTHDLLFGNQAT
PEQFSTWTASLPSNPGLVDYSLEPLHTLLEEQNPKREALRQAISHYIMSR
ARWQNCSRPCCQCECQDSKVTNQDCCPRQRGLAHLVVSNFRAEHLWGDYT
TATDAYLKVFFGGQEFRTGVVWNNNNPRWTDKMDFENVLLSTGGPLRVQV
WDADYGWDDDLLGSCDRSPHSGFHEVTCELNHGRVKFSYHAKCLPHLTGG
TCLEYAPQG
3D structure
PDB7pag The pore conformation of lymphocyte perforin.
ChainA
Resolution4.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D429 T432 A433 D435 N454 D398 T401 A402 D404 N423
BS02 CA A D429 D435 D483 A484 D485 D398 D404 D452 A453 D454
BS03 CA A G428 Y430 D483 D485 D491 G397 Y399 D452 D454 D460
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0022829 wide pore channel activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0140911 pore-forming activity
Biological Process
GO:0001771 immunological synapse formation
GO:0001909 leukocyte mediated cytotoxicity
GO:0001913 T cell mediated cytotoxicity
GO:0002357 defense response to tumor cell
GO:0002418 immune response to tumor cell
GO:0009306 protein secretion
GO:0017038 protein import
GO:0031640 killing of cells of another organism
GO:0051260 protein homooligomerization
GO:0051607 defense response to virus
GO:0051712 positive regulation of killing of cells of another organism
GO:0071806 protein transmembrane transport
GO:0140507 granzyme-mediated programmed cell death signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005576 extracellular region
GO:0005764 lysosome
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0031904 endosome lumen
GO:0044194 cytolytic granule

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pag, PDBe:7pag, PDBj:7pag
PDBsum7pag
PubMed35148176
UniProtP10820|PERF_MOUSE Perforin-1 (Gene Name=Prf1)

[Back to BioLiP]