Structure of PDB 7p8v Chain A

Receptor sequence
>7p8vA (length=331) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGG
AKLIRIRDNGCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALA
SISSVSRLTLTSRTAEQQEAWQAYAEGRDMNVTVKPAAHPVGTTLEVLDL
FYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYR
AVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVADPNHTTPAL
AEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQ
3D structure
PDB7p8v MutL binds to 3' resected DNA ends and blocks DNA polymerase access.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R22 R162 T163 R266 N269 H270 R273 R316 H319 R22 R162 T163 R266 N269 H270 R273 R316 H319
BS02 ANP A N33 A37 I63 T77 S78 K79 G93 R95 A98 L99 K307 N33 A37 I63 T77 S78 K79 G93 R95 A98 L99 K307
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0042802 identical protein binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0070716 mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
Cellular Component
GO:0017117 single-stranded DNA-dependent ATP-dependent DNA helicase complex
GO:0032300 mismatch repair complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7p8v, PDBe:7p8v, PDBj:7p8v
PDBsum7p8v
PubMed35670670
UniProtP23367|MUTL_ECOLI DNA mismatch repair protein MutL (Gene Name=mutL)

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