Structure of PDB 7p5t Chain A

Receptor sequence
>7p5tA (length=396) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
EAPDVDLADGNFYASREARAAYRWMRANQPVFRDRNGLAAASTYQAVIDA
ERQPELFSNAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
EASIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMF
LRWSDDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLV
SVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQ
WDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMM
LLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLARLELSL
MTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPPLG
3D structure
PDB7p5t Structure of CYP142 from Mycobacterium tuberculosis in complex with inhibitor MEK216
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.15.28: cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming].
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0031073 cholesterol 26-hydroxylase activity
GO:0036199 cholest-4-en-3-one 26-monooxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0006707 cholesterol catabolic process
GO:0008203 cholesterol metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7p5t, PDBe:7p5t, PDBj:7p5t
PDBsum7p5t
PubMed
UniProtP9WPL5|CP142_MYCTU Steroid C26-monooxygenase (Gene Name=cyp142)

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