Structure of PDB 7p5o Chain A

Receptor sequence

>7p5oA (length=556) Species: 746128 (Aspergillus fumigatus)

LGSMSVQTVSIQPFTDQKPGTSGLRKKVKVFQQPHYSEAFVTSILLSIPE
GAEGAFLVIGGDGRYYNPEVIQKIAKISAAYGVKKLLIGQNGILSTPAAS
NLIRVRKATGGILLTASHNPGGPNADFGIKYNLCNGAPAPESVTNKIYET
SKSLTSYKIAEIPDVDTSTIGTKTYGPLEVEIVHSTSDYLKMLKEIFDFD
LIKEFLSTHKDFKVLFDGMHGVTGPYGVDIFVKELGLPQDSTMNCVPSPD
FNGGHPDPNLVYAHELVEAVDKKGIHFGAASDGDGDRNMIYGANTFVSPG
DSLAIIAHHAKLIPWFQKQGVYGLARSMPTSGAVDLVAKAQGLQSYEVPT
GWKFFCNLFDNKKISICGEESFGTGSNHIREKDGVWAIVAWLNIIAGVAK
QKPNETPSIASIQNEFWQTYGRTFFTRYDYENVDSDAANKLIANLSEKIN
NSFVGSTVSGRKVADAGNFAYTDLDGSVTKNQGLYVKFDDGSRLVVRLSG
TGSSGATIRLYIEKYESDKSKFGMNTQDYLKDNVALAMSLLKFKEYIGRE
DPDVKT

3D structure

• PDB: 7p5o Targeting an essential step in the biosynthetic pathway of uridine diphosphate glucose in Aspergillus fumigatus
• Chain: A
• Resolution: 2.48 Å

Enzymatic activity

• Enzyme Commision number: 5.4.2.2: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	G16	A	T18 R22 S114 H115 K127 R284 T347 E366 S368 K379 R496 S498 G499 T500 R508	T21 R25 S117 H118 K130 R287 T350 E369 S371 K382 R497 S499 G500 T501 R509
BS02	MG	A	S114 D279 D281 D283	S117 D282 D284 D286

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004614 phosphoglucomutase activity
• GO:0016853 isomerase activity
• GO:0016868 intramolecular phosphotransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0006006 glucose metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7p5o, PDBe:7p5o, PDBj:7p5o
• PDBsum: 7p5o
• UniProt: Q4WY53|PGM_ASPFU Phosphoglucomutase (Gene Name=pgmA)