Structure of PDB 7p4q Chain A

Receptor sequence
>7p4qA (length=303) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
HHHHHMVDEILKLKKEKGYIILAHNYQIPELQDIADFVGDSLQLARKAME
LSEKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANRLTPEIIREY
REKFPDAPVVLYVNSTSECKTLADVICTAANAVEVVKKLDSSVVIFGPDR
NLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPE
CPKPVRDKADYVGSTGQMEKIPERDPSRIFVIGTEIGMIHKLKKKFPDRE
FVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFE
LMG
3D structure
PDB7p4q Transient Formation of a Second Active Site Cavity during Quinolinic Acid Synthesis by NadA.
ChainA
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.72: quinolinate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A Y21 C81 N109 C168 V170 C254 Y26 C86 N114 C173 V175 C259
BS02 F3S A Y21 C81 N109 C168 C254 Y26 C86 N114 C173 C259
Gene Ontology
Molecular Function
GO:0008987 quinolinate synthetase A activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019805 quinolinate biosynthetic process
GO:0034628 'de novo' NAD biosynthetic process from aspartate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7p4q, PDBe:7p4q, PDBj:7p4q
PDBsum7p4q
PubMed34609124
UniProtQ9X1X7|NADA_THEMA Quinolinate synthase (Gene Name=nadA)

[Back to BioLiP]