Structure of PDB 7p3j Chain A

Receptor sequence
>7p3jA (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
FKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGE
IRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ
CIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG
VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN
PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCW
KPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGN
QVGKLYVWDLECTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDR
3D structure
PDB7p3j Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
ChainA
Resolution1.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L9W A F97 Y148 N194 K211 L240 D310 Y365 M366 R367 R414 F16 Y67 N113 K130 L159 D229 Y284 M285 R286 R325
External links
PDB RCSB:7p3j, PDBe:7p3j, PDBj:7p3j
PDBsum7p3j
PubMed34807608
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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