Structure of PDB 7p1p Chain A

Receptor sequence
>7p1pA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
TGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDT
PEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLA
GVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPV
AQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDP
SRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYV
SLDLRPLEVRRGLRAQACAFWNRFLPKLLSAT
3D structure
PDB7p1p A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.
ChainA
Resolution3.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.7: acetylcholinesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4IX A W286 E292 Y341 W25 E31 Y80
Gene Ontology
Molecular Function
GO:0004104 cholinesterase activity

View graph for
Molecular Function
External links
PDB RCSB:7p1p, PDBe:7p1p, PDBj:7p1p
PDBsum7p1p
PubMed35255209
UniProtP22303|ACES_HUMAN Acetylcholinesterase (Gene Name=ACHE)

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