Structure of PDB 7p0x Chain A

Receptor sequence
>7p0xA (length=576) Species: 6279 (Brugia malayi) [Search protein sequence]
SLADAVFKSACEERILLAYADYNPDMTKVVNLFSKYNETVNTVRVSNDAV
KDILEIVGWPSMPLIFVKGNCCGGFKELYQLEESGFLNEWLKEHEYDLAI
VGGGSGGLAAAKEAVRLGKKVVCLDFVKPSAMGTTWGLGGTCVNVGCIPK
KLMHQAALLGEYIEDAKKFGWEIPEGAIKLNWHQLKNAVQNHIASLNWGY
RVQLKEKSVTYMNSYATFTGSHELSVKNKKGKVEKVTADRFLIAVGLRPR
FPDVPGALECCISSDDLFSLPYNPGKTLCVGASYVSLECAGFLKGIGNDV
TVMVRSVLLRGFDQDMAERIKKHMTERGVKFVQCVPIKYERLKKPTDSEP
GMIRVHTMQEDEDGTKEVTEDFNTVLMAIGRDAMTDDLGLDVVGVNRAKS
GKIIGRREQSVSCPYVYAIGDVLYGSPELTPVAIQAGKVLMRRLFTGSSE
LTEYDKIPTTVFTPLEYGSCGLSEYSAIQKYGKENINVYHNVFIPLEYAV
TERKEKTHCYCKLICLKNEQDLILGFHILTPNAGEITQGFAIALKFDAKK
ADFDRLIGIHPTVAENFTTLTLVKED
3D structure
PDB7p0x Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.8.1.9: thioredoxin-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A V112 S116 G117 D136 F137 T152 G157 C158 K161 Y226 A227 V256 G257 Y295 V296 R392 G431 D432 E439 L440 T441 V101 S105 G106 D125 F126 T141 G146 C147 K150 Y215 A216 V245 G246 Y284 V285 R381 G420 D421 E428 L429 T430
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0045454 cell redox homeostasis

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Molecular Function
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Biological Process
External links
PDB RCSB:7p0x, PDBe:7p0x, PDBj:7p0x
PDBsum7p0x
PubMed35276442
UniProtA0A1I9G0T9

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