Structure of PDB 7p0m Chain A

Receptor sequence
>7p0mA (length=534) Species: 9606 (Homo sapiens) [Search protein sequence]
EKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTR
NYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQ
LRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIK
GHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLE
LLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVS
GYVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGV
RNLQKQVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDV
TPPGVVMGLAWTAMGGSTLFVETSLRRPGDKDGSLEVTGQLGEVMKESAR
IAYTFARAFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALL
SLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEATIAAKRAGVTCIVLPAE
NKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPD
3D structure
PDB7p0m A dual allosteric pathway drives human mitochondrial Lon
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.53: endopeptidase La.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y565 V566 Y599 Q600 Y156 V157 Y190 Q191
BS02 peptide A A769 W770 P850 D852 S855 A360 W361 P435 D437 S440
BS03 ATP A H491 Y492 P525 G526 V527 G528 K529 T530 S531 Y661 I669 V709 R710 H82 Y83 P116 G117 V118 G119 K120 T121 S122 Y252 I260 V300 R301
Gene Ontology
Molecular Function
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003727 single-stranded RNA binding
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008236 serine-type peptidase activity
GO:0016887 ATP hydrolysis activity
GO:0042731 PH domain binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0043560 insulin receptor substrate binding
GO:0043565 sequence-specific DNA binding
GO:0051880 G-quadruplex DNA binding
GO:0070182 DNA polymerase binding
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0001666 response to hypoxia
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0007005 mitochondrion organization
GO:0030163 protein catabolic process
GO:0032042 mitochondrial DNA metabolic process
GO:0034599 cellular response to oxidative stress
GO:0035694 mitochondrial protein catabolic process
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0051131 chaperone-mediated protein complex assembly
GO:0051603 proteolysis involved in protein catabolic process
GO:0070407 oxidation-dependent protein catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0016020 membrane
GO:0042645 mitochondrial nucleoid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7p0m, PDBe:7p0m, PDBj:7p0m
PDBsum7p0m
PubMed
UniProtP36776|LONM_HUMAN Lon protease homolog, mitochondrial (Gene Name=LONP1)

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