Structure of PDB 7p06 Chain A

Receptor sequence

>7p06A (length=1350) Species: 559292 (Saccharomyces cerevisiae S288C)

DPKLDPNSENFSSAAWVKNMAHLSAADPDFYKPYSLGCAWKNLSASGASA
DVAYQSTVVNIPYKILKSGLRKFNTFQILKPMDGCLNPGELLVVLGRPGS
GCTTLLKSISSNTHGFDLGADTKISYSGYSGDDIKKHFRGEVVYNAEADV
HLPHLTVFETLVTVARLKTPQNRIKGVDRESYANHLAEVAMATYGLSHTR
NTKVGNDIVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSATALEF
IRALKTQADISNTSATVAIYQCSQDAYDLFNKVCVLDDGYQIYYGPADKA
KKYFEDMGYVCPSRQTTADFLTSVTSPSERTLNKDMLKKGIHIPQTPKEM
NDYWVKSPNYKELMKEVDQRLLNDDEASREAIKEAHIAKQSKRARPSSPY
TVSYMMQVKYLLIRNMWRLRNNIGFTLFMILGNCSMALILGSMFFKIMKK
GDTSTFYFRGSAMFFAILFNAFSSLLEIFSLYEARPITEKHRTYSLYHPS
ADAFASVLSEIPSKLIIAVCFNIIFYFLVDFRRNGGVFFFYLLINIVAVF
SMSHLFRCVGSLTKTLSEAMVPASMLLLALSMYTGFAIPKKKILRWSKWI
WYINPLAYLFESLLINEFHGIKFPCAEYVPRGPAYANISSTESVCTVVGA
VPGQDYVLGDDFIRGTYQYYHKDKWRGFGIGMAYVVFFFFVYLFLCEYNE
GAKQKGEILVFPRSIVKRMGLSKSEAIFHWRNLCYEVQIKAETRRILNNV
DGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGDILVNGIPRDKS
FPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPAEVSIEEKNRYVEEVIK
ILEMEKYADAVVGVAGEGLNVEQRKRLTIGVELTAKPKLLVFLDEPTSGL
DSQTAWSICQLMKKLANHGQAILCTIHQPSAILMQEFDRLLFMQRGGKTV
YFGDLGEGCKTMIDYFESHGAHKCPADANPAEWMLEVVGAAPGSHANQDY
YEVWRNSEEYRAVQSELDWMERELPHEFSQSIIYQTKLVSIRLFQQYWRS
PDYLWSKFILTIFNQLFIGFTFFKAGTSLQGLQNQMLAVFMFTVIFNPIL
QQYLPSFVQQRDLYEARERPSRTFSWISFIFAQIFVEVPWNILAGTIAYF
IYYYPIGFYSNASAAGQLHERGALFWLFSCAFYVYVGSMGLLVISFNQVA
ESAANLASLLFTMSLSFCGVMTTPSAMPRFWIFMYRVSPLTYFIQALLAV
GVANVDVKCADYELLEFTPPSGMTCGQYMEPYLQLAKTGYLTDENATDTC
SFCQISTTNDYLANVNSFYSERWRNYGIFICYIAFNYIAGVFFYWLARVP

3D structure

• PDB: 7p06 Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5.
• Chain: A
• Resolution: 3.77 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	A	I175 G196 G198 T200 T201 E244 Y367 E804 N1011	I78 G99 G101 T103 T104 E147 Y270 E707 N870
BS02	MG	A	T912 Q951	T771 Q810
BS03	AOV	A	T299 R307 S310 G312 E313 V878 I880 I887 S907 G908 A909 G910 K911 T912 T913 M924 Q951 H1068	T202 R210 S213 G215 E216 V737 I739 I746 S766 G767 A768 G769 K770 T771 T772 M783 Q810 H927

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0008559 ABC-type xenobiotic transporter activity
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0042802 identical protein binding
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0009410 response to xenobiotic stimulus
• GO:0030003 intracellular monoatomic cation homeostasis
• GO:0046677 response to antibiotic
• GO:0046898 response to cycloheximide
• GO:0055085 transmembrane transport
• GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane

Cellular Component

• GO:0005739 mitochondrion
• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0071944 cell periphery

External links

• PDB: RCSB:7p06, PDBe:7p06, PDBj:7p06
• PDBsum: 7p06
• PubMed: 34489436
• UniProt: P33302|PDR5_YEAST Pleiotropic ABC efflux transporter of multiple drugs (Gene Name=PDR5)