Structure of PDB 7p05 Chain A

Receptor sequence

>7p05A (length=1353) Species: 559292 (Saccharomyces cerevisiae S288C)

NYNGFDEHTEARIQKLARTLTAQSMQDPKLDPNSENFSSAAWVKNMAHLS
AADPDFYKPYSLGCAWKNLSASGASADVAYQSTVVNIPYKILKSGLRKFQ
TNTFQILKPMDGCLNPGELLVVLGRPGSGCTTLLKSISSNTHGFDLGADT
KISYSGYSGDDIKKHFRGEVVYNAEADVHLPHLTVFETLVTVARLKTPQN
RIKGVDRESYANHLAEVAMATYGLSHTRNTKVGNDIVRGVSGGERKRVSI
AEVSICGSKFQCWDNATRGLDSATALEFIRALKTQADISNTSATVAIYQC
SQDAYDLFNKVCVLDDGYQIYYGPADKAKKYFEDMGYVCPSRQTTADFLT
SVTSPSERTLNKDMLKKGIHIPQTPKEMNDYWVKSPNYKELMKEVDQRLL
NPYTVSYMMQVKYLLIRNMWRLRNNIGFTLFMILGNCSMALILGSMFFKI
MKKGDTSTFYFRGSAMFFAILFNAFSSLLEIFSLYEARPITEKHRTYSLY
HPSADAFASVLSEIPSKLIIAVCFNIIFYFLVDFRRNGGVFFFYLLINIV
AVFSMSHLFRCVGSLTKTLSEAMVPASMLLLALSMYTGFAIPKKKILRWS
KWIWYINPLAYLFESLLINEFHGIKFPCAEYVPRGPAYANISSTESVCTV
VGAVPGQDYVLGDDFIRGTYQYYHKDKWRGFGIGMAYVVFFFFVYLFLCE
YNEGAKQKGEILVFPRSIVKRMGLSKSEAIFHWRNLCYEVQIKAETRRIL
NNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGDILVNGIPR
DKSFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPAEVSIEEKNRYVEE
VIKILEMEKYADAVVGVAGEGLNVEQRKRLTIGVELTAKPKLLVFLDEPT
SGLDSQTAWSICQLMKKLANHGQAILCTIHQPSAILMQEFDRLLFMQRGG
KTVYFGDLGEGCKTMIDYFESHGAHKCPADANPAEWMLEVVGAAPGSHAN
QDYYEVWRNSEEYRAVQSELDWMERELPHEFSQSIIYQTKLVSIRLFQQY
WRSPDYLWSKFILTIFNQLFIGFTFFKAGTSLQGLQNQMLAVFMFTVIFN
PILQQYLPSFVQQRDLYEARERPSRTFSWISFIFAQIFVEVPWNILAGTI
AYFIYYYPIGFYSNASAAGQLHERGALFWLFSCAFYVYVGSMGLLVISFN
QVAESAANLASLLFTMSLSFCGVMTTPSAMPRFWIFMYRVSPLTYFIQAL
LAVGVANVDVKCADYELLEFTPPSGMTCGQYMEPYLQLAKTGYLTDENAT
DTCSFCQISTTNDYLANVNSFYSERWRNYGIFICYIAFNYIAGVFFYWLA
RVP

3D structure

• PDB: 7p05 Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5.
• Chain: A
• Resolution: 3.13 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	A	F173 I175 G196 G198 C199 T200 T201 D333 Q801 G803	F104 I106 G127 G129 C130 T131 T132 D264 Q707 G709
BS02	ADP	A	R885 I887 G908 G910 K911 T912 T913 M924	R747 I749 G770 G772 K773 T774 T775 M786
BS03	RHQ	A	M526 N530 F566 F569 S570 S571 L573 L674 N1357 S1360 L1361	M432 N436 F472 F475 S476 S477 L479 L580 N1208 S1211 L1212

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0008559 ABC-type xenobiotic transporter activity
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0042802 identical protein binding
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0009410 response to xenobiotic stimulus
• GO:0030003 intracellular monoatomic cation homeostasis
• GO:0046677 response to antibiotic
• GO:0046898 response to cycloheximide
• GO:0055085 transmembrane transport
• GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane

Cellular Component

• GO:0005739 mitochondrion
• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0071944 cell periphery

External links

• PDB: RCSB:7p05, PDBe:7p05, PDBj:7p05
• PDBsum: 7p05
• PubMed: 34489436
• UniProt: P33302|PDR5_YEAST Pleiotropic ABC efflux transporter of multiple drugs (Gene Name=PDR5)