Structure of PDB 7oyg Chain A

Receptor sequence

>7oygA (length=814) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]

VYRAFDIYNDKVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILV
TYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMR
NAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTL
TRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPN
CVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYH
FRELGVVHNQDVNLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALT
NNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISD
YDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSA
GFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKN
RARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNML
KTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRF
YRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTA
NVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKH
FSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTE
TDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDG
TLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTDNTSRY
WEPEFYEAMYTPHT

3D structure

PDB

7oyg The structure of a dimeric form of SARS-CoV-2 polymerase

Chain

Resolution

5.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	L758 D760 C813 R836 L854 R858 S861 D865	L656 D658 C711 R734 L752 R756 S759 D763
BS02	rna	A	N496 K500 S501 N543 V557 G559 R569 G590 S592 F594 S682 G683 D684 A685 Y915 M924	N394 K398 S399 N441 V455 G457 R467 G488 S490 F492 S580 G581 D582 A583 Y800 M809
BS03	ZN	A	H295 C301 C306	H198 C204 C209
BS04	ZN	A	C487 H642 C645 C646	C385 H540 C543 C544

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003968	RNA-dependent RNA polymerase activity
GO:0005524	ATP binding

	Biological Process
GO:0006351	DNA-templated transcription
GO:0039694	viral RNA genome replication

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7oyg, PDBe:7oyg, PDBj:7oyg
PDBsum	7oyg
PubMed
UniProt	P0DTD1\|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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