Structure of PDB 7oy1 Chain A

Receptor sequence
>7oy1A (length=334) Species: 1924,1950,1114943 [Search protein sequence]
IDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPE
ALLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRAWHDLTQAV
ARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLMATA
VDEAPAAAYDWTNVRHVLDVGGGNGGFAAAIARRAPHVSATVLEMAGTVD
TARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHDAVRI
LTRCAEALEPGGRILIHERADVADRFFSTLLDLRMLVFLGGALRTREKWD
GLAASAGLVVEEVRGPLVSPNVPLDSSLLVLAPA
3D structure
PDB7oy1 Evolution-inspired engineering of anthracycline methyltransferases.
ChainA
Resolution2.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.292: carminomycin 4-O-methyltransferase.
4.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y143 R153 G187 G188 E210 M211 G236 D237 F238 S252 Y130 R140 G171 G172 E194 M195 G220 D221 F222 S236
BS02 3VL A F156 M160 T162 F253 N257 L300 L301 R304 M305 F143 M147 T149 F237 N241 L280 L281 R284 M285
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7oy1, PDBe:7oy1, PDBj:7oy1
PDBsum7oy1
PubMed36874276
UniProtI2N5E8;
Q06528|DNRK_STRPE Carminomycin 4-O-methyltransferase DnrK (Gene Name=dnrK);
Q54527|RDMB_STREF Aclacinomycin 10-hydroxylase RdmB (Gene Name=rdmB)

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