Structure of PDB 7oy0 Chain A

Receptor sequence

>7oy0A (length=462) Species: 9606 (Homo sapiens) [Search protein sequence]

PGPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHIGGRVQSVKLGHA
TFELGATWIHGSHGNPIYHLAEANGLLENGVACYLTNHGRRIPKDVVEEF
SDLYNEVYNLTQEFFVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLK
LAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFMRVVE
LLAEGIPAHVIQLGKPVRCIHWDQASGSVVVECEDCELIPADHVIVTVSL
GVLKRQYTSFFRPGLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSL
QFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEAL
VMETLSDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSY
TQVGSSGADVEKLAKPLPGLQVLFSGEATHRKYYSTTHGALLSGQREAAR
LIEMYRDLFQQS

3D structure

PDB

7oy0 Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor.

Chain

Resolution

2.09 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.5.3.16: spermine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	6YU	A	I10 G11 G13 A15 L34 E35 A36 G42 R43 G57 A58 T59 W60 P240 V241 T275 V276 W416 Y421 F422 S425 Y426 G454 E455 S463 T464 T465 A468	I8 G9 G11 A13 L32 E33 A34 G40 R41 G55 A56 T57 W58 P216 V217 T247 V248 W388 Y393 F394 S397 Y398 G426 E427 S435 T436 T437 A440
BS02	3EI	A	Y181 E185 M194 V197 W205 E207	Y157 E161 M170 V173 W181 E183

Gene Ontology

	Molecular Function
GO:0016491	oxidoreductase activity

View graph for
Molecular Function

External links

PDB	RCSB:7oy0, PDBe:7oy0, PDBj:7oy0
PDBsum	7oy0
PubMed	35931745
UniProt	Q9NWM0\|SMOX_HUMAN Spermine oxidase (Gene Name=SMOX)

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