Structure of PDB 7oxl Chain A

Receptor sequence
>7oxlA (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]
PGPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHIGGRVQSVKLGHA
TFELGATWIHGSHGNPIYHLAEANGLLENGVACYLTNHGRRIPKDVVEEF
SDLYNEVYNLTQEFFVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLK
LAMIQQYLKVESCESSAHHIIPSGFMRVVELLAEGIPAHVIQLGKPVRCI
HWDQASGSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKV
AAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELW
YRKICGFDVLYPPERYGHVLSGWICGEEALVMETLSDEAVAEICTEMLRQ
FTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPGL
QVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQS
3D structure
PDB7oxl Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.3.16: spermine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6YU A I10 G11 G13 A15 E35 A36 G42 R43 G57 A58 T59 W60 E188 P240 V241 V276 W371 W416 Y421 F422 S425 G454 E455 S463 T464 T465 A468 I8 G9 G11 A13 E33 A34 G40 R41 G55 A56 T57 W58 E164 P196 V197 V228 W323 W368 Y373 F374 S377 G406 E407 S415 T416 T417 A420
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:7oxl, PDBe:7oxl, PDBj:7oxl
PDBsum7oxl
PubMed35931745
UniProtQ9NWM0|SMOX_HUMAN Spermine oxidase (Gene Name=SMOX)

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