Structure of PDB 7oxb Chain A

Receptor sequence
>7oxbA (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
MGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAI
KELRSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGC
LLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT
PQHVKITDFGRAKLLGHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVT
VWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMI
DADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPMDEEDMDDVVDAD
EYLIP
3D structure
PDB7oxb Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors".
ChainA
Resolution2.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 35Z A L718 F723 A743 K745 M793 P794 G796 C797 D800 R841 L844 D855 L24 F29 A49 K51 M96 P97 G99 C100 D103 R144 L147 D158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7oxb, PDBe:7oxb, PDBj:7oxb
PDBsum7oxb
PubMed34624491
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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