Structure of PDB 7owb Chain A

Receptor sequence
>7owbA (length=333) Species: 1950,2202516 [Search protein sequence]
QIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRP
EALLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRAWHDLTQA
VARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLLAC
DQDVAFDAPAAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMA
GTVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHD
AVRILTRCAEALEPGGRILIHERAETADLHFSLLDLRMLVFLGGALRTRE
KWDGLAASAGLVVEEVRQLTIPYDLSLLVLAPA
3D structure
PDB7owb Evolution-inspired engineering of anthracycline methyltransferases.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.292: carminomycin 4-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3VL A W106 F156 F253 H300 L303 L304 M308 W94 F144 F241 H280 L283 L284 M288
BS02 SAH A Y143 R153 L160 G187 E210 M211 D237 F238 S252 Y131 R141 L148 G175 E198 M199 D225 F226 S240
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7owb, PDBe:7owb, PDBj:7owb
PDBsum7owb
PubMed36874276
UniProtA0A2V2Q0Q4;
Q06528|DNRK_STRPE Carminomycin 4-O-methyltransferase DnrK (Gene Name=dnrK)

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