Structure of PDB 7ovn Chain A

Receptor sequence
>7ovnA (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
QTGYLTIGGQRYQAEINDLENLGEMGSGTQVWKMRFRKTGHVIAVKQMRR
SGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCA
EKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDE
RGQIKLCDFGISGRAGCAAYMAPERIDPPDDIRADVWSLGISLVELATGQ
FPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRP
KYNKLLEHSFIKRYETLEVDVASWFKDVMAKTE
3D structure
PDB7ovn Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.
ChainA
Resolution2.9 Å
3D
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Enzymatic activity
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2I8 A K152 E213 L214 M215 G216 C218 L266 K33 E94 L95 M96 G97 C99 L147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ovn, PDBe:7ovn, PDBj:7ovn
PDBsum7ovn
PubMed35912476
UniProtO14733|MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (Gene Name=MAP2K7)

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