Structure of PDB 7ovk Chain A

Receptor sequence
>7ovkA (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
QTGYLTIGGQRYQAEINDLENLGEMGGQVWKMRFRKTGHVIAVKQMRRSG
NKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEK
LKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERG
QIKLCDFADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPG
HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFK
DVMAKT
3D structure
PDB7ovk Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2I5 A M142 G143 L183 M212 M215 C218 S263 D277 M25 G26 L62 M91 M94 C97 S142 D156
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ovk, PDBe:7ovk, PDBj:7ovk
PDBsum7ovk
PubMed35912476
UniProtO14733|MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (Gene Name=MAP2K7)

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