Structure of PDB 7ov8 Chain A

Receptor sequence
>7ov8A (length=303) Species: 9823 (Sus scrofa) [Search protein sequence]
TPTPILRFVAVGDWGGVPNAPFHTAREMANAKAIATTVKTLGADFILSLG
DNFYFTGVHDAKDKRFQETFEDVFSDPSLRNVPWHVLAGNHDHLGNVSAQ
IAYSKISKRWNFPSPYYRLRFKIPRSNVSVAIFMLDTVTLCGNSDDFVSQ
QPERPRNLALARTQLAWIKKQLAAAKEDYVLVAGHYPVWSIAEHGPTHCL
VKQLLPLLTTHKVTAYLCGHDHNLQYLQDENGLGFVLSGAGNFMDPSKKH
LRKVPNGYLRFHFGAENSLGGFAYVEITPKEMSVTYIEASGKSLFKTKLP
RRA
3D structure
PDB7ov8 Rational Design of Potent Inhibitors of a Metallohydrolase Using a Fragment-Based Approach.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.2: acid phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EPE A S115 Y117 Y118 S114 Y116 Y117
BS02 EPE A H94 N144 D147 H93 N143 D146
BS03 EPE A H199 K203 H198 K202
BS04 FE A D52 N91 H186 H221 D51 N90 H185 H220
BS05 FE A D14 D52 Y55 H223 D13 D51 Y54 H222
BS06 PO4 A D52 Y55 N91 H92 H195 H221 H223 D51 Y54 N90 H91 H194 H220 H222
Gene Ontology
Molecular Function
GO:0003993 acid phosphatase activity
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:7ov8, PDBe:7ov8, PDBj:7ov8
PDBsum7ov8
PubMed34331400
UniProtP09889|PPA5_PIG Tartrate-resistant acid phosphatase type 5 (Gene Name=ACP5)

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