Structure of PDB 7ov3 Chain A

Receptor sequence
>7ov3A (length=302) Species: 9823 (Sus scrofa) [Search protein sequence]
PTPILRFVAVGDWGGVPNAPFHTAREMANAKAIATTVKTLGADFILSLGD
NFYFTGVHDAKDKRFQETFEDVFSDPSLRNVPWHVLAGNHDHLGNVSAQI
AYSKISKRWNFPSPYYRLRFKIPRSNVSVAIFMLDTVTLCGNSDDFVSQQ
PERPRNLALARTQLAWIKKQLAAAKEDYVLVAGHYPVWSIAEHGPTHCLV
KQLLPLLTTHKVTAYLCGHDHNLQYLQDENGLGFVLSGAGNFMDPSKKHL
RKVPNGYLRFHFGAENSLGGFAYVEITPKEMSVTYIEASGKSLFKTKLPR
RA
3D structure
PDB7ov3 Rational Design of Potent Inhibitors of a Metallohydrolase Using a Fragment-Based Approach.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.2: acid phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R2J A Q152 H251 K254 Q150 H249 K252
BS02 R2J A D147 F148 V149 D145 F146 V147
BS03 R2J A K249 H263 F264 G265 A266 K247 H261 F262 G263 A264
BS04 PO4 A D52 Y55 N91 H92 H195 H221 H223 D50 Y53 N89 H90 H193 H219 H221
BS05 FE A D52 N91 H186 H221 D50 N89 H184 H219
BS06 FE A D14 D52 Y55 H223 D12 D50 Y53 H221
Gene Ontology
Molecular Function
GO:0003993 acid phosphatase activity
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006826 iron ion transport
GO:0045453 bone resorption
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ov3, PDBe:7ov3, PDBj:7ov3
PDBsum7ov3
PubMed34331400
UniProtP09889|PPA5_PIG Tartrate-resistant acid phosphatase type 5 (Gene Name=ACP5)

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