Structure of PDB 7ou0 Chain A

Receptor sequence
>7ou0A (length=711) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
HTPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKRG
AEPIPMAGIPYHAVENYLAKLVNQGESVAICEQIGVERKVVRIVTPGTIS
DEALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAEL
QRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTR
DLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLPHIRSITMEREQDSIIMD
AATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRV
LLERQQTIGALQDFTAGLQPVLRQVGDLERILARLALRTARPRDLARMRH
AFQQLPELRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVR
DGGVIASGYNEELDEWRALADGKVLTSKGKALALEKQLYEELFDLLLPHL
EALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVE
QVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSY
VPAQKVEIGPIDRIFTRVGAADDLASGRSTFMVEMTETANILHNATEYSL
VLMDEIGRGTSTYDGLSLAWACAENLANKIKALTLFATHYFELTQLPEKM
EGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRA
RQKLRELESIS
3D structure
PDB7ou0 Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair.
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A V588 L592 F596 I597 M617 G619 K620 S621 T622 H760 V499 L503 F507 I508 M528 G530 K531 S532 T533 H671
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008301 DNA binding, bending
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0032136 adenine/cytosine mispair binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006974 DNA damage response
Cellular Component
GO:0005829 cytosol
GO:0032300 mismatch repair complex
GO:1990710 MutS complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ou0, PDBe:7ou0, PDBj:7ou0
PDBsum7ou0
PubMed35013597
UniProtP23909|MUTS_ECOLI DNA mismatch repair protein MutS (Gene Name=mutS)

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