Structure of PDB 7otf Chain A

Receptor sequence
>7otfA (length=195) Species: 9606 (Homo sapiens) [Search protein sequence]
LPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNA
FLWQSYQVKKRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCKNA
VSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLV
TPPPKNPHNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA
3D structure
PDB7otf Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs.
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1H9 A H559 G560 S585 Y586 Y591 Y598 S599 Y604 H78 G79 S102 Y103 Y108 Y115 S116 Y121
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7otf, PDBe:7otf, PDBj:7otf
PDBsum7otf
PubMed34801828
UniProtQ460N3|PAR15_HUMAN Protein mono-ADP-ribosyltransferase PARP15 (Gene Name=PARP15)

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